Role of Reactive Oxygen Species in Pathophysiology of Various Disorders
DOI:
https://doi.org/10.62382/f50qrf37Keywords:
Oxidative stress, Alzheimer’s disease, Parkinson’s disease, Reactive oxygen speciesAbstract
Oxidative stress occurs when the body cannot efficiently eliminate reactive metabolic by-products, leading to excessive accumulation of reactive oxygen species (ROS) in cells and tissues. While ROS are normal metabolites that play essential signaling roles, various external factors-such as UV radiation, pollution, heavy metals, and certain drugs, including anticancer agents-can elevate ROS levels and disrupt redox balance. This imbalance induces cellular and tissue damage, triggering the activation of antioxidant defence mechanisms. Natural antioxidants like vitamin E, flavonoids, and polyphenols have gained research interest for their potential to counteract oxidative injury. Although the harmful effects of oxidative stress on human health are well established, its therapeutic targeting, particularly in oncology, remains debated since reducing ROS may influence treatment outcomes. This review summarizes recent insights into oxidative stress, highlighting both its detrimental and potentially beneficial roles in human health.
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Copyright (c) 2025 Suniti Verma, Deepanshu Kharb (Author)
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