Platelet-Rich Plasma Drug Delivery System for the Treatment of Osteoporosis
DOI:
https://doi.org/10.62382/gp2r2b61Keywords:
Osteoporosis, Treatment system, Platelet derivatives, Hydrogels, BiomaterialsAbstract
Osteoporosis affects millions of people worldwide and presents significant challenges for treatment, characterized by decreased bone density and increased fracture risk. While conventional treatments such as hormone replacement therapy can alleviate symptoms, they often fail to reverse bone loss and are associated with long-term side effects. Platelet-rich plasma (PRP), known for its regenerative potential, has emerged as a promising approach for the treatment of osteoporosis. This review evaluates the efficacy of PRP-based drug delivery systems for the treatment of osteoporosis and presents key findings from clinical, in vitro, and in vivo studies. PRP has been shown to improve bone regeneration and fracture healing in patients, enhancing bone mineral density and structural integrity. In vitro studies have shown that PRP promotes osteoblast proliferation and differentiation, thereby supporting bone formation. In vivo animal models have further confirmed the ability of PRP to increase bone volume and trabecular thickness, highlighting its therapeutic promise. We analyze the biological mechanisms driving the effects of PRP, including growth factor release and cell signaling, and explore innovative PRP formulations, such as hydrogels and scaffolds, designed for targeted delivery. Despite these advances, challenges such as standardization of PRP preparation and long-term safety remain. This article reviews these results, emphasizes the potential of PRP to transform osteoporosis treatment through a regenerative strategy, and proposes future studies to improve its clinical applicability and efficacy.
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